English
norskBlar i forfatter "Johnsen, Stein Harald"
Viser treff 1-20 av 24
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Amyloid plaques and symptoms of depression links to medical help-seeking due to subjective cognitive decline
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-02)<i>Background:</i> Subjective cognitive decline (SCD) is associated with an increased risk of Alzheimer’s disease (AD). However, patients reporting SCD to their general practitioner are not always referred to a memory clinic.<p> <p><i>Objective:</i> To investigate whether prior history of medical help-seeking is associated with AD biomarker abnormality, worse cognitive performance, and/or depressive ... -
The association between anthropometric measures of adiposity and the progression of carotid atherosclerosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-17)<i>Background</i> - Few reports are available on the contribution of general and abdominal obesity to the progression of carotid atherosclerosis in late adulthood. This study investigated the impact of four simple anthropometric measures of general and abdominal obesity on the progression of carotid atherosclerosis and the extent to which the association between adiposity and the progression of ... -
Brain amyloid and vascular risk are related to distinct white matter hyperintensity patterns
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-21)White matter hyperintensities (WMHs) are associated with vascular risk and Alzheimer’s disease. In this study, we examined relations between WMH load and distribution, amyloid pathology and vascular risk in 339 controls and cases with either subjective (SCD) or mild cognitive impairment (MCI). Regional deep (DWMH) and periventricular (PWMH) WMH loads were determined using an automated algorithm. We ... -
Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-29)<p><i>Background</i>: Creatine kinase (CK) has been associated with reduced inflammation in obesity while inflammation is associated with obesity-related cardiovascular diseases. We investigated the relationship between CK and high sensitive C-reactive protein (hs-CRP) in a general population.</p> <p><i>Methods</i>: CK and hs-CRP were measured in the population-based Tromsø study that included ... -
Demographically adjusted CERAD wordlist test norms in a Norwegian sample from 40 to 80 years
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-08)<i>Background/Objective</i>: In recent years, several slightly younger cohorts have been established in order to study the preclinical and prodromal phases of dementia. The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) wordlist memory test (WLT) is widely used in dementia research. However, culturally adapted and demographically adjusted test norms for younger ages are ... -
Dietary intake of marine n-3 polyunsaturated fatty acids and future risk of venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)<p><i>Background</i>: Studies on the association between long‐chained n‐3 polyunsaturated fatty acids (n‐3 PUFAs) and risk of venous thromboembolism (VTE) are conflicting, potentially due to challenges related to assessment of n‐3 PUFA intake and changes in diet during follow‐up.</p> <p><i>Objectives</i>: To investigate whether dietary intake of marine n‐3 PUFAs was associated with risk of incident ... -
Evaluation of error production in animal fluency and its relationship to frontal tracts in normal aging and mild Alzheimer's disease: A combined LDA and time-course analysis investigation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-12)Semantic verbal fluency (VF), assessed by animal category, is a task widely used for early detection of dementia. A feature not regularly assessed is the occurrence of errors such as perseverations and intrusions. So far, no investigation has analyzed the how and when of error occurrence during semantic VF in aging populations, together with their possible neural correlates. The present study aims ... -
Evaluation of Serum 25-Hydroxyvitamin D as a Predictor of Carotid Intima-Media Thickness and Carotid Total Plaque Area in Nonsmokers: The Tromso Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Objective. Altered calcium homeostasis has been linked to increased intima-media thickness (IMT) and plaques. We aimed to investigate whether serum 25-hydroxyvitamin D (25(OH)D) and serum calcium are associated with IMT and plaques in nonsmoking population. Methods.Ultrasound of the right carotid arterywith themeasurements of IMT and plaqueswas performed in 4194 nonsmoking subjects with available ... -
Fish consumption, fish oil supplements and risk of atherosclerosis in the Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-25)Background: <br>Whether long-chain n–3 PUFAs of marine origin have an anti-atherogenic effect in the general population has hardly been studied. In this population-based study, we hypothesized that fatty fish and fish oil intake protect against development of novel atherosclerotic plaques and is associated with reduced plaque size.<br> Methods: <br>We obtained questionnaire-based information ... -
Healthcare professionals' knowledge of modifiable stroke risk factors: A cross-sectional questionnaire survey in greater Gaborone, Botswana
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-27)Background - Stroke remains the second leading cause of deaths and disability globally, with highest mortality in Africa (low- and middle-income countries). It is crucial for healthcare professionals to have sufficient stroke risk factors' knowledge in order to reduce the stroke burden. <p> <p>Aims - We investigated healthcare professionals' knowledge of modifiable stroke risk factors, and ... -
Joint Effect of Carotid Plaque and C-Reactive Protein on First-Ever Ischemic Stroke and Myocardial Infarction?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-17)Background: <br>The joint effect of atherosclerosis and CRP (C-reactive protein) on risk of ischemic stroke (IS) and myocardial infarction (MI) has been sparsely studied. The aim of this study was to explore whether CRP mediates the risk of events in subjects with prevalent carotid plaque, examine synergism, and test whether CRP and carotid plaque add to risk prediction beyond traditional risk ... -
Long-Term Use of Lipid-Lowering Drugs Slows Progression of Carotid Atherosclerosis The Tromso Study 1994 to 2008
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Data on the effect of lipid-lowering drugs (LLD) on carotid atherosclerosis outside clinical trials are limited. The aim of this study was to determine the effect of LLD on change in carotid intima media thickness and total plaque area in a general population. Subjects were 1532 women and 1442 men who participated in a longitudinal population-based study with ultrasound examination of intima media ... -
The metabolic syndrome and progression of carotid atherosclerosis over 13 years. The Tromsø study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)The metabolic syndrome (MetS) is associated with increased risk of cardiovascular disease. In this study, we examine if metabolic syndrome predicts progression of atherosclerosis over 13 years. Participants were 1442 men and 1532 women in the population-based Tromsø Study who underwent carotid ultrasound examinations at baseline in the 4th (1994–5) and at follow-up in the 6th survey (2007–8). Of ... -
Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration
(Journal article; Peer reviewed; Tidsskriftartikkel, 2018-04-12)<b>Aims</b><br> Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk.<br> <b>Methods and results</b><br> From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts ... -
Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-16)<i>Aims</i> - Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear.<p> <p><i>Methods and results</i> - An individual participant meta-analysis was used to associate the annualised progression of systolic ... -
Public and outpatients’ awareness of calling emergency medical services immediately by acute stroke in an upper middle-income country: a cross-sectional questionnaire study in greater Gaborone, Botswana
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-14)Objectives - In this cross-sectional study from Botswana, we investigated awareness of calling emergency medical services (EMS) and seeking immediate medical assistance by acute stroke among stroke risk outpatients and public.<p> <p>Method - Closed-ended questionnaires on awareness of calling EMS and seeking immediate medical assistance by acute stroke, were administered by research assistants ... -
Red cell distribution width and carotid atherosclerosis progression: The Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-29)Red cell distribution width (RDW), a measure of the size variability of circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with progression of atherosclerotic plaques in subjects recruited from the general population. Baseline characteristics, including RDW, were collected from 4677 participants in the fourth survey ... -
Repeated measurements of carotid atherosclerosis and future risk of venous thromboembolism: the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-05)<p><i>Background</i>: Whether a relationship between atherosclerosis and subsequent venous thromboembolism (VTE) exists is controversial.</p> <p><i>Objective</i>: To investigate the association between carotid atherosclerosis and VTE by using repeated measurements of intima media thickness (IMT) and total plaque area (TPA) in participants recruited from the general population.</p> <p><i>Methods</i>: ... -
Risk Factors for Progression of Carotid Intima-Media Thickness and Total Plaque Area A 13-Year Follow-Up Study: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Data on risk factors for progression of intima-media thickness (IMT) and plaque are scarce. The objective was to determine long-term risk factors for total plaque area (TPA) and IMT as well as risk factors for progression (ΔTPA and ΔIMT). Subjects were 1307 men and 1436 women who participated in a longitudinal population-based study with ultrasound examination of the right carotid artery at baseline ... -
Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-19)Background - Current evidence supports the use of intravenous thrombolysis with alteplase in patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in clinical guidelines. However, access to advanced imaging techniques is often scarce. We aimed to determine whether thrombolytic treatment with intravenous tenecteplase given within 4·5 h of awakening improves functional ...
